Cadmium in PDB 7icu: Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar)

The structure of Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar), PDB code: 7icu was solved by H.Pelletier, M.R.Sawaya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 3.30
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	177.493, 57.682, 48.510, 90.00, 90.00, 90.00
R / Rfree (%)	16.5 / n/a

The structure of Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar) also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

The binding sites of Cadmium atom in the Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar) (pdb code 7icu). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total only one binding site of Cadmium was determined in the Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar), PDB code: 7icu:

Cadmium binding site 1 out of 1 in the Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Dna Polymerase Beta (Pol B) (E.C.2.7.7.7) Complexed with Six Base Pairs of Dna; Soaked in the Presence of CDCL2 (0.1 Millimolar) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd343 b:47.5 occ:1.00 ND1 A:HIS51 3.0 37.0 1.0 CE1 A:HIS51 3.6 35.9 1.0 CG A:HIS51 4.2 38.9 1.0 CB A:HIS51 4.7 40.4 1.0 NE2 A:HIS51 4.8 32.6 1.0 O A:PRO50 4.9 43.7 1.0

H.Pelletier, M.R.Sawaya, W.Wolfle, S.H.Wilson, J.Kraut. A Structural Basis For Metal Ion Mutagenicity and Nucleotide Selectivity in Human Dna Polymerase Beta. Biochemistry V. 35 12762 1996.
ISSN: ISSN 0006-2960
PubMed: 8841119
DOI: 10.1021/BI9529566