Cadmium in PDB 1elm: Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form.

All present enzymatic activity of Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form.:
3.4.17.1;

The structure of Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form., PDB code: 1elm was solved by F.Jensen, T.Bukrinsky, J.Bjerrum, S.Larsen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	47.163, 60.244, 51.746, 90.00, 97.41, 90.00
R / Rfree (%)	16.1 / 18.6

The binding sites of Cadmium atom in the Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form. (pdb code 1elm). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form., PDB code: 1elm:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form.


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form. within 5.0Å range: probe atom residue distance (Å) B Occ P:Cd350 b:13.6 occ:1.00 ND1 P:HIS69 2.4 9.7 1.0 O P:HOH401 2.4 10.9 1.0 OE2 P:GLU72 2.4 8.8 1.0 ND1 P:HIS196 2.4 10.2 1.0 OE1 P:GLU72 2.6 8.1 1.0 O P:HOH550 2.6 20.6 1.0 CD P:GLU72 2.9 9.0 1.0 CE1 P:HIS69 3.3 10.0 1.0 CG P:HIS196 3.4 7.8 1.0 CG P:HIS69 3.4 8.0 1.0 CE1 P:HIS196 3.5 9.9 1.0 CB P:HIS196 3.5 8.6 1.0 CB P:HIS69 3.7 8.3 1.0 O P:HOH402 4.0 19.9 1.0 O P:SER197 4.1 9.7 1.0 OE2 P:GLU270 4.2 13.3 1.0 CG P:GLU72 4.3 8.3 1.0 NH2 P:ARG127 4.4 20.5 1.0 O P:HOH403 4.5 12.3 1.0 NE2 P:HIS69 4.5 11.1 1.0 CA P:HIS196 4.5 9.1 1.0 CD2 P:HIS69 4.5 9.0 1.0 N P:SER197 4.6 8.5 1.0 CD2 P:HIS196 4.6 10.3 1.0 NE2 P:HIS196 4.6 10.0 1.0 O P:HOH606 4.8 35.0 1.0 OE1 P:GLU270 4.9 12.8 1.0 CD P:GLU270 4.9 13.5 1.0

Cadmium binding site 2 out of 2 in the Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form.


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Cadmium-Substituted Bovine Pacreatic Carboxypeptidase A (Alfa-Form) at pH 5.5 and 2 Mm Chloride in Monoclinic Crystal Form. within 5.0Å range: probe atom residue distance (Å) B Occ P:Cd351 b:26.7 occ:0.15 ND1 P:HIS303 2.3 27.0 1.0 CE1 P:HIS303 3.0 26.0 1.0 CG P:HIS303 3.5 24.9 1.0 OE2 P:GLU218 3.8 22.8 1.0 CB P:HIS303 4.1 22.9 1.0 NE2 P:HIS303 4.2 25.9 1.0 O P:HIS303 4.5 22.5 1.0 CD2 P:HIS303 4.5 25.3 1.0 CG2 P:VAL222 4.6 11.4 1.0 CA P:HIS303 4.6 21.6 1.0 CD P:GLU218 4.6 21.6 1.0 CG P:GLU218 4.8 19.0 1.0 OH P:TYR265 4.8 18.7 1.0

F.Jensen, T.Bukrinsky, J.Bjerrum, S.Larsen. Three High-Resolution Crystal Structures of Cadmium-Substituted Carboxypeptidase A Provide Insight Into the Enzymatic Function J.Biol.Inorg.Chem. V. 7 490 2002.
ISSN: ISSN 0949-8257
PubMed: 11941507
DOI: 10.1007/S00775-001-0324-0