Cadmium in PDB 2hcr: Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion

All present enzymatic activity of Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion:
2.7.6.1;

The structure of Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion, PDB code: 2hcr was solved by S.Li, B.Peng, J.Ding, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	25.00 / 2.20
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	170.236, 170.236, 61.820, 90.00, 90.00, 120.00
R / Rfree (%)	20.5 / 25.4

The binding sites of Cadmium atom in the Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion (pdb code 2hcr). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion, PDB code: 2hcr:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd2002 b:83.5 occ:0.60 OD1 A:ASP171 2.6 36.7 1.0 OD2 A:ASP171 3.0 35.0 1.0 OD1 A:ASP220 3.1 37.5 1.0 CG A:ASP171 3.2 35.8 1.0 OD2 A:ASP220 3.2 38.3 1.0 CG A:ASP220 3.6 37.9 1.0 OD2 A:ASP221 4.4 38.3 1.0 NH1 A:ARG177 4.5 44.0 1.0 N A:GLY174 4.6 40.3 1.0 O3P A:AMP3001 4.6 68.0 1.0 CB A:ASP171 4.7 35.9 1.0 CE1 A:HIS130 4.7 23.5 1.0 CA A:GLY174 4.9 40.0 1.0

Cadmium binding site 2 out of 2 in the Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Crystal Structure of Human Phosphoribosyl Pyrophosphate Synthetase 1 in Complex with Amp(Atp), Cadmium and Sulfate Ion within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd2001 b:42.4 occ:0.60 OD2 B:ASP171 2.5 30.8 1.0 OD1 B:ASP220 2.7 30.2 1.0 OD1 B:ASP171 2.8 31.1 1.0 CG B:ASP171 3.0 31.2 1.0 OD2 B:ASP220 3.2 31.1 1.0 CG B:ASP220 3.3 29.4 1.0 OD1 B:ASP221 4.0 30.7 1.0 N B:GLY174 4.2 34.9 1.0 CA B:GLY174 4.4 35.4 1.0 CB B:ASP171 4.5 31.1 1.0 C B:GLY173 4.6 34.7 1.0 CB B:ASP220 4.8 28.3 1.0 CE1 B:HIS130 4.8 23.4 1.0 CA B:GLY173 5.0 34.2 1.0 O B:HOH3084 5.0 30.7 1.0

S.Li, Y.Lu, B.Peng, J.Ding. Crystal Structure of Human Phosphoribosylpyrophosphate Synthetase 1 Reveals A Novel Allosteric Site Biochem.J. V. 401 39 2007.
ISSN: ISSN 0264-6021
PubMed: 16939420
DOI: 10.1042/BJ20061066