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Cadmium in PDB 2w2c: Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta

Enzymatic activity of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta

All present enzymatic activity of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta:
2.7.11.17;

Protein crystallography data

The structure of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta, PDB code: 2w2c was solved by A.C.W.Pike, P.Rellos, R.Sethi, E.Salah, N.Burgess-Brown, L.Shrestha, A.Roos, J.W.Murray, F.Von Delft, A.Edwards, C.H.Arrowsmith, J.Weigelt, C.Bountra, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.80 / 2.70
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 149.546, 117.803, 160.761, 90.00, 111.92, 90.00
R / Rfree (%) 21.1 / 24.5

Cadmium Binding Sites:

The binding sites of Cadmium atom in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta (pdb code 2w2c). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 6 binding sites of Cadmium where determined in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta, PDB code: 2w2c:
Jump to Cadmium binding site number: 1; 2; 3; 4; 5; 6;

Cadmium binding site 1 out of 6 in 2w2c

Go back to Cadmium Binding Sites List in 2w2c
Cadmium binding site 1 out of 6 in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cd1472

b:82.3
occ:0.40
 O B:HOH2006 1.9 27.1 1.0
O B:HOH2009 2.1 20.2 1.0
OD2 B:ASP425 2.5 43.6 1.0
OD1 B:ASP425 2.8 48.4 1.0
CG B:ASP425 2.9 43.8 1.0
NE B:ARG457 4.0 53.7 1.0
CD B:ARG457 4.3 50.4 1.0
CB B:ASP425 4.4 40.1 1.0
O B:ARG457 4.7 42.4 1.0
CB B:ARG457 4.9 42.5 1.0

Cadmium binding site 2 out of 6 in 2w2c

Go back to Cadmium Binding Sites List in 2w2c
Cadmium binding site 2 out of 6 in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Cd1472

b:96.8
occ:0.40
 OD2 F:ASP425 2.1 46.8 1.0
CG F:ASP425 2.7 45.1 1.0
OD1 F:ASP425 2.8 44.1 1.0
CB F:ASP425 4.0 43.7 1.0

Cadmium binding site 3 out of 6 in 2w2c

Go back to Cadmium Binding Sites List in 2w2c
Cadmium binding site 3 out of 6 in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Cd1472

b:78.5
occ:0.40
 OD2 H:ASP424 2.5 47.7 1.0
OD1 H:ASP424 3.1 44.2 1.0
CG H:ASP424 3.1 45.7 1.0
NH1 H:ARG346 4.3 56.8 1.0
NH2 H:ARG346 4.5 57.1 1.0
CB H:ASP424 4.5 44.8 1.0
N H:ASP424 4.8 43.9 1.0
CZ H:ARG346 4.9 56.5 1.0
CA H:ASP424 4.9 44.6 1.0

Cadmium binding site 4 out of 6 in 2w2c

Go back to Cadmium Binding Sites List in 2w2c
Cadmium binding site 4 out of 6 in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 4 of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cd1472

b:79.0
occ:0.40
 OD2 J:ASP425 2.3 48.8 1.0
CD J:CD1474 2.8 94.5 0.4
OD1 J:ASP425 2.9 48.9 1.0
CG J:ASP425 2.9 47.2 1.0
CB J:ASP425 4.4 44.8 1.0

Cadmium binding site 5 out of 6 in 2w2c

Go back to Cadmium Binding Sites List in 2w2c
Cadmium binding site 5 out of 6 in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 5 of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cd1473

b:77.5
occ:0.40
 OD2 J:ASP424 2.4 44.3 1.0
OD1 J:ASP424 2.5 45.4 1.0
CG J:ASP424 2.8 44.9 1.0
CB J:ASP424 4.3 44.3 1.0

Cadmium binding site 6 out of 6 in 2w2c

Go back to Cadmium Binding Sites List in 2w2c
Cadmium binding site 6 out of 6 in the Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 6 of Structure of the Tetradecameric Oligomerisation Domain of Calcium- Calmodulin Dependent Protein Kinase II Delta within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Cd1474

b:94.5
occ:0.40
 OD2 J:ASP425 2.6 48.8 1.0
CD J:CD1472 2.8 79.0 0.4
CG J:ASP425 3.0 47.2 1.0
OD1 J:ASP425 3.1 48.9 1.0
CB J:ASP424 3.4 44.3 1.0
OD2 J:ASP424 4.2 44.3 1.0
CB J:ASP425 4.2 44.8 1.0
N J:ASP425 4.3 44.4 1.0
CG J:ASP424 4.3 44.9 1.0
C J:ASP424 4.4 44.4 1.0
CA J:ASP424 4.5 44.3 1.0
CA J:ASP425 4.8 44.7 1.0
O J:ASP424 4.9 44.5 1.0

Reference:

P.Rellos, A.C.W.Pike, F.H.Niesen, E.Salah, W.H.Lee, F.Von Delft, S.Knapp. Structure of the Camkiidelta/Calmodulin Complex Reveals the Molecular Mechanism of Camkii Kinase Activation. Plos Biol. V. 8 426 2010.
ISSN: ISSN 1544-9173
PubMed: 20668654
DOI: 10.1371/JOURNAL.PBIO.1000426
Page generated: Fri Jul 19 15:18:15 2024

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