Atomistry » Cadmium » PDB 2wxt-3a05 » 2x7k
Atomistry »
  Cadmium »
    PDB 2wxt-3a05 »
      2x7k »

Cadmium in PDB 2x7k: The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip

Enzymatic activity of The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip

All present enzymatic activity of The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip:
5.2.1.8;

Protein crystallography data

The structure of The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip, PDB code: 2x7k was solved by C.M.Stegmann, R.Luehrmann, M.C.Wahl, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.28 / 1.15
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 103.218, 35.701, 45.851, 90.00, 90.00, 90.00
R / Rfree (%) 12.8 / 14.9

Other elements in 2x7k:

The structure of The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip also contains other interesting chemical elements:

Sodium (Na) 1 atom

Cadmium Binding Sites:

The binding sites of Cadmium atom in the The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip (pdb code 2x7k). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip, PDB code: 2x7k:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in 2x7k

Go back to Cadmium Binding Sites List in 2x7k
Cadmium binding site 1 out of 2 in the The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cd1167

b:7.1
occ:1.00
NE2 A:HIS31 2.3 7.8 1.0
OD2 A:ASP89 2.3 8.0 1.0
OD1 A:ASP89 2.4 7.7 1.0
O A:HOH2190 2.4 9.4 1.0
O A:HOH2087 2.5 33.8 1.0
CG A:ASP89 2.7 8.2 1.0
CE1 A:HIS31 3.3 10.0 1.0
CD2 A:HIS31 3.3 7.0 1.0
HE1 A:HIS31 3.4 12.1 1.0
HD2 A:HIS31 3.4 8.4 1.0
CB A:ASP89 4.2 7.2 1.0
HB3 A:HIS87 4.2 9.3 1.0
ND1 A:HIS31 4.4 9.9 1.0
CG A:HIS31 4.4 6.0 1.0
HG A:LEU90 4.4 12.3 1.0
HB2 A:ASP89 4.5 8.7 1.0
HB3 A:ASP89 4.6 8.7 1.0
ND1 A:HIS87 4.8 7.3 1.0
H A:ASP89 4.9 7.9 1.0
HE3 A:LYS30 4.9 41.5 0.3
CB A:HIS87 5.0 7.8 1.0

Cadmium binding site 2 out of 2 in 2x7k

Go back to Cadmium Binding Sites List in 2x7k
Cadmium binding site 2 out of 2 in the The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of The Crystal Structure of PPIL1 in Complex with Cyclosporine A Suggests A Binding Mode For Skip within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cd1168

b:7.6
occ:0.99
OE1 A:GLU26 2.2 9.6 1.0
O A:HOH2239 2.5 6.4 1.0
SG A:CYS133 2.5 7.5 1.0
CD A:GLU26 2.8 8.7 1.0
OE2 A:GLU26 2.9 9.9 1.0
HB2 A:CYS133 3.2 8.6 1.0
HH21 A:ARG131 3.2 12.9 1.0
HA A:CYS133 3.3 9.7 1.0
CB A:CYS133 3.4 7.2 1.0
HE A:ARG131 3.6 10.5 1.0
NH2 A:ARG131 3.8 10.7 1.0
CA A:CYS133 3.9 8.1 1.0
NE A:ARG131 4.2 8.7 1.0
HB3 A:CYS133 4.2 8.6 1.0
CG A:GLU26 4.2 8.2 1.0
HH22 A:ARG131 4.3 12.9 1.0
CZ A:ARG131 4.4 9.6 1.0
HG2 A:GLU26 4.4 9.8 1.0
O A:HOH2244 4.5 29.6 1.0
HG3 A:ARG131 4.7 7.9 1.0
HG3 A:GLU26 4.8 9.8 1.0
HB3 A:GLU26 4.8 9.3 1.0
C A:CYS133 4.9 10.0 1.0
N A:CYS133 4.9 6.6 1.0
O A:CYS133 4.9 15.3 1.0

Reference:

C.M.Stegmann, R.Luehrmann, M.C.Wahl. The Crystal Structure of PPIL1 Bound to Cyclosporine A Suggests A Binding Mode For A Linear Epitope of the Skip Protein. Plos One V. 5 13 2010.
ISSN: ESSN 1932-6203
PubMed: 20368803
DOI: 10.1371/JOURNAL.PONE.0010013
Page generated: Thu Jul 10 12:13:05 2025

Last articles

Cl in 3QIH
Cl in 3QIP
Cl in 3QI3
Cl in 3QHW
Cl in 3QEH
Cl in 3QHR
Cl in 3QGT
Cl in 3QHD
Cl in 3QGN
Cl in 3QGF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy