Cadmium in PDB 3fgh: Human Mitochondrial Transcription Factor A Box B

The structure of Human Mitochondrial Transcription Factor A Box B, PDB code: 3fgh was solved by T.A.Gangelhoff, P.Mungalachetty, J.Nix, M.E.A.Churchill, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.00 / 1.35
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	30.280, 99.350, 51.910, 90.00, 90.00, 90.00
R / Rfree (%)	18.8 / 21.4

The structure of Human Mitochondrial Transcription Factor A Box B also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Sodium	(Na)	2 atoms

The binding sites of Cadmium atom in the Human Mitochondrial Transcription Factor A Box B (pdb code 3fgh). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Human Mitochondrial Transcription Factor A Box B, PDB code: 3fgh:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Human Mitochondrial Transcription Factor A Box B


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Human Mitochondrial Transcription Factor A Box B within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd1 b:10.6 occ:1.00 O A:HOH46 1.9 34.2 1.0 OE2 A:GLU166 2.2 11.1 1.0 CL A:CL179 2.5 11.8 1.0 CL A:CL178 2.5 12.7 1.0 OE1 A:GLU166 2.5 10.1 1.0 CD A:GLU166 2.7 10.2 1.0 CG A:GLU166 4.2 11.3 1.0 CB A:ALA162 4.6 12.7 1.0 O A:HOH57 4.7 11.0 0.5

Cadmium binding site 2 out of 2 in the Human Mitochondrial Transcription Factor A Box B


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Human Mitochondrial Transcription Factor A Box B within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd2 b:14.7 occ:1.00 OD2 A:ASP152 2.3 13.7 1.0 O A:HOH28 2.3 19.2 1.0 OD1 A:ASP152 2.4 13.7 1.0 CG A:ASP152 2.7 13.2 1.0 O A:HOH24 3.8 14.5 1.0 CB A:ASP152 4.3 12.1 1.0 O A:HOH6 4.4 22.0 1.0

T.A.Gangelhoff, P.S.Mungalachetty, J.C.Nix, M.E.Churchill. Structural Analysis and Dna Binding of the Hmg Domains of the Human Mitochondrial Transcription Factor A Nucleic Acids Res. V. 37 3153 2009.
ISSN: ISSN 0305-1048
PubMed: 19304746
DOI: 10.1093/NAR/GKP157