Cadmium in PDB 3hmw: Crystal Structure of Ustekinumab Fab

The structure of Crystal Structure of Ustekinumab Fab, PDB code: 3hmw was solved by J.Luo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.83 / 3.00
Space group	P 63 2 2
Cell size a, b, c (Å), α, β, γ (°)	139.310, 139.310, 114.580, 90.00, 90.00, 120.00
R / Rfree (%)	22.8 / 28.7

The binding sites of Cadmium atom in the Crystal Structure of Ustekinumab Fab (pdb code 3hmw). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Crystal Structure of Ustekinumab Fab, PDB code: 3hmw:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Crystal Structure of Ustekinumab Fab


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Crystal Structure of Ustekinumab Fab within 5.0Å range: probe atom residue distance (Å) B Occ L:Cd215 b:30.6 occ:0.50 OD2 L:ASP1 2.1 51.8 1.0 O L:ASP1 2.1 36.1 1.0 N L:ASP1 2.4 33.1 1.0 C L:ASP1 2.8 42.5 1.0 CA L:ASP1 3.0 50.6 1.0 CG L:ASP1 3.0 51.5 1.0 CB L:ASP1 3.5 50.5 1.0 OE1 L:GLN3 3.6 47.7 1.0 OD1 L:ASP1 4.1 52.9 1.0 N L:ILE2 4.1 39.8 1.0 CD L:GLN3 4.5 46.9 1.0 CG L:GLN3 4.6 46.7 1.0 O L:HOH229 4.7 16.2 0.5 CA L:ILE2 4.8 38.4 1.0 O L:HOH217 4.8 8.6 1.0

Cadmium binding site 2 out of 2 in the Crystal Structure of Ustekinumab Fab


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Crystal Structure of Ustekinumab Fab within 5.0Å range: probe atom residue distance (Å) B Occ L:Cd216 b:78.5 occ:0.50 O L:HOH231 2.4 25.9 0.5 NE2 L:HIS189 2.7 64.8 1.0 CE1 L:HIS189 3.2 68.5 1.0 OD2 L:ASP185 3.6 66.2 1.0 CD2 L:HIS189 3.7 67.3 1.0 OD1 L:ASP185 3.7 73.5 1.0 CG L:ASP185 4.1 69.0 1.0 ND1 L:HIS189 4.2 73.2 1.0 CG L:HIS189 4.5 69.7 1.0

J.Luo, S.J.Wu, E.R.Lacy, Y.Orlovsky, A.Baker, A.Teplyakov, G.Obmolova, G.A.Heavner, H.T.Richter, J.Benson. Structural Basis For the Dual Recognition of Il-12 and Il-23 By Ustekinumab. J.Mol.Biol. V. 402 797 2010.
ISSN: ISSN 0022-2836
PubMed: 20691190
DOI: 10.1016/J.JMB.2010.07.046