Cadmium in PDB 3i55: Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
Protein crystallography data
The structure of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit, PDB code: 3i55
was solved by
G.Gurel,
G.Blaha,
T.A.Steitz,
P.B.Moore,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
49.98 /
3.11
|
Space group
|
C 2 2 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
211.324,
299.649,
574.241,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
21 /
26
|
Other elements in 3i55:
The structure of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit also contains other interesting chemical elements:
Cadmium Binding Sites:
The binding sites of Cadmium atom in the Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
(pdb code 3i55). This binding sites where shown within
5.0 Angstroms radius around Cadmium atom.
In total 5 binding sites of Cadmium where determined in the
Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit, PDB code: 3i55:
Jump to Cadmium binding site number:
1;
2;
3;
4;
5;
Cadmium binding site 1 out
of 5 in 3i55
Go back to
Cadmium Binding Sites List in 3i55
Cadmium binding site 1 out
of 5 in the Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
Mono view
Stereo pair view
|
A full contact list of Cadmium with other atoms in the Cd binding
site number 1 of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
O:Cd8705
b:0.2
occ:1.00
|
O
|
O:HOH5650
|
2.5
|
53.1
|
1.0
|
ND1
|
O:HIS40
|
2.8
|
48.8
|
1.0
|
O
|
O:HOH5322
|
3.1
|
79.5
|
1.0
|
CG
|
O:HIS40
|
3.7
|
49.1
|
1.0
|
CE1
|
O:HIS40
|
3.7
|
48.4
|
1.0
|
CB
|
O:HIS40
|
3.8
|
50.4
|
1.0
|
CG
|
O:ARG37
|
4.6
|
59.4
|
1.0
|
CZ
|
O:ARG37
|
4.6
|
58.2
|
1.0
|
O
|
O:HOH3002
|
4.7
|
65.8
|
1.0
|
CB
|
O:ARG37
|
4.8
|
58.8
|
1.0
|
NH2
|
O:ARG37
|
4.8
|
57.9
|
1.0
|
NE
|
O:ARG37
|
4.8
|
58.3
|
1.0
|
NH1
|
O:ARG37
|
4.8
|
56.4
|
1.0
|
NE2
|
O:HIS40
|
4.9
|
49.0
|
1.0
|
CD2
|
O:HIS40
|
4.9
|
49.3
|
1.0
|
O
|
O:HOH7077
|
4.9
|
46.0
|
1.0
|
CA
|
O:ARG37
|
4.9
|
58.1
|
1.0
|
|
Cadmium binding site 2 out
of 5 in 3i55
Go back to
Cadmium Binding Sites List in 3i55
Cadmium binding site 2 out
of 5 in the Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
Mono view
Stereo pair view
|
A full contact list of Cadmium with other atoms in the Cd binding
site number 2 of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
U:Cd8701
b:0.0
occ:1.00
|
CB
|
U:CYS36
|
3.0
|
0.3
|
1.0
|
SG
|
U:CYS6
|
3.1
|
0.9
|
1.0
|
CB
|
U:TYR8
|
3.3
|
0.8
|
1.0
|
N
|
U:CYS32
|
3.4
|
0.1
|
1.0
|
CA
|
U:PHE31
|
3.6
|
0.9
|
1.0
|
CD2
|
U:PHE31
|
3.7
|
0.7
|
1.0
|
CB
|
U:PHE31
|
3.8
|
0.4
|
1.0
|
CD2
|
U:TYR8
|
3.9
|
0.9
|
1.0
|
SG
|
U:CYS36
|
3.9
|
0.9
|
1.0
|
N
|
U:CYS9
|
3.9
|
0.7
|
1.0
|
C
|
U:PHE31
|
4.0
|
0.7
|
1.0
|
CG
|
U:TYR8
|
4.0
|
0.0
|
1.0
|
CG
|
U:PHE31
|
4.1
|
0.9
|
1.0
|
SG
|
U:CYS32
|
4.2
|
0.9
|
1.0
|
SG
|
U:CYS9
|
4.2
|
1.0
|
1.0
|
CA
|
U:TYR8
|
4.3
|
0.2
|
1.0
|
CA
|
U:CYS36
|
4.3
|
0.8
|
1.0
|
N
|
U:SER33
|
4.4
|
0.5
|
1.0
|
CB
|
U:CYS9
|
4.4
|
0.8
|
1.0
|
C
|
U:CYS36
|
4.5
|
0.3
|
1.0
|
N
|
U:TYR8
|
4.5
|
0.2
|
1.0
|
CA
|
U:CYS32
|
4.5
|
0.3
|
1.0
|
O
|
U:HIS30
|
4.5
|
0.3
|
1.0
|
O
|
U:SER33
|
4.6
|
0.4
|
1.0
|
CB
|
U:CYS32
|
4.6
|
0.9
|
1.0
|
C
|
U:TYR8
|
4.6
|
0.8
|
1.0
|
CE2
|
U:PHE31
|
4.7
|
0.4
|
1.0
|
O
|
U:CYS36
|
4.8
|
0.7
|
1.0
|
N
|
U:PHE31
|
4.8
|
0.3
|
1.0
|
CA
|
U:CYS9
|
4.8
|
0.8
|
1.0
|
OG
|
U:SER33
|
4.8
|
0.1
|
1.0
|
N
|
U:GLU37
|
4.9
|
0.1
|
1.0
|
CB
|
U:CYS6
|
4.9
|
0.2
|
1.0
|
C
|
U:CYS32
|
5.0
|
1.0
|
1.0
|
|
Cadmium binding site 3 out
of 5 in 3i55
Go back to
Cadmium Binding Sites List in 3i55
Cadmium binding site 3 out
of 5 in the Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
Mono view
Stereo pair view
|
A full contact list of Cadmium with other atoms in the Cd binding
site number 3 of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
Z:Cd8703
b:0.0
occ:1.00
|
CB
|
Z:CYS84
|
2.9
|
0.4
|
1.0
|
CB
|
Z:ASN65
|
3.4
|
0.8
|
1.0
|
SG
|
Z:CYS66
|
3.4
|
0.1
|
1.0
|
SG
|
Z:CYS81
|
3.4
|
0.7
|
1.0
|
N
|
Z:CYS84
|
3.7
|
0.5
|
1.0
|
N
|
Z:CYS66
|
3.8
|
0.6
|
1.0
|
CB
|
Z:CYS66
|
3.8
|
0.9
|
1.0
|
CA
|
Z:CYS84
|
3.8
|
0.3
|
1.0
|
CB
|
Z:CYS81
|
4.1
|
0.9
|
1.0
|
CD2
|
Z:TYR83
|
4.1
|
0.7
|
1.0
|
C
|
Z:ASN65
|
4.1
|
0.9
|
1.0
|
CA
|
Z:ASN65
|
4.2
|
0.2
|
1.0
|
CB
|
Z:TYR86
|
4.2
|
0.1
|
1.0
|
SG
|
Z:CYS84
|
4.2
|
0.5
|
1.0
|
CB
|
Z:CYS63
|
4.4
|
0.9
|
1.0
|
C
|
Z:CYS84
|
4.4
|
0.8
|
1.0
|
CA
|
Z:CYS66
|
4.4
|
0.9
|
1.0
|
N
|
Z:ASN65
|
4.5
|
0.6
|
1.0
|
SG
|
Z:CYS63
|
4.5
|
0.1
|
1.0
|
CG
|
Z:ASN65
|
4.6
|
0.6
|
1.0
|
CB
|
Z:TYR83
|
4.7
|
0.6
|
1.0
|
N
|
Z:TYR86
|
4.7
|
0.4
|
1.0
|
ND2
|
Z:ASN65
|
4.8
|
0.4
|
1.0
|
N
|
Z:ASP85
|
4.8
|
0.4
|
1.0
|
O
|
Z:ASN65
|
4.9
|
0.7
|
1.0
|
CG
|
Z:TYR83
|
4.9
|
0.2
|
1.0
|
C
|
Z:TYR83
|
4.9
|
0.1
|
1.0
|
O
|
Z:CYS63
|
4.9
|
0.2
|
1.0
|
O
|
Z:CYS84
|
5.0
|
0.4
|
1.0
|
CE2
|
Z:TYR83
|
5.0
|
0.2
|
1.0
|
|
Cadmium binding site 4 out
of 5 in 3i55
Go back to
Cadmium Binding Sites List in 3i55
Cadmium binding site 4 out
of 5 in the Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
Mono view
Stereo pair view
|
A full contact list of Cadmium with other atoms in the Cd binding
site number 4 of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
1:Cd8702
b:78.5
occ:1.00
|
SG
|
1:CYS37
|
2.4
|
52.5
|
1.0
|
SG
|
1:CYS34
|
2.5
|
45.4
|
1.0
|
SG
|
1:CYS22
|
2.5
|
47.2
|
1.0
|
SG
|
1:CYS19
|
2.5
|
49.9
|
1.0
|
CB
|
1:CYS22
|
3.1
|
48.0
|
1.0
|
CB
|
1:CYS19
|
3.2
|
49.0
|
1.0
|
CB
|
1:CYS34
|
3.2
|
41.0
|
1.0
|
CB
|
1:CYS37
|
3.3
|
47.6
|
1.0
|
N
|
1:CYS22
|
3.5
|
49.9
|
1.0
|
N
|
1:CYS37
|
3.8
|
46.8
|
1.0
|
CA
|
1:CYS22
|
3.9
|
48.0
|
1.0
|
CB
|
1:PHE39
|
4.0
|
57.6
|
1.0
|
CA
|
1:CYS37
|
4.1
|
47.6
|
1.0
|
N
|
1:PHE39
|
4.6
|
53.7
|
1.0
|
C
|
1:CYS22
|
4.6
|
46.9
|
1.0
|
CB
|
1:ARG21
|
4.6
|
47.8
|
1.0
|
N
|
1:GLY23
|
4.6
|
45.5
|
1.0
|
C
|
1:CYS37
|
4.6
|
47.4
|
1.0
|
C
|
1:ARG21
|
4.7
|
50.7
|
1.0
|
CA
|
1:CYS34
|
4.7
|
42.3
|
1.0
|
CA
|
1:CYS19
|
4.7
|
49.0
|
1.0
|
CB
|
1:SER36
|
4.8
|
43.1
|
1.0
|
N
|
1:GLY38
|
4.8
|
48.3
|
1.0
|
N
|
1:ARG21
|
4.9
|
50.5
|
1.0
|
CD
|
1:ARG21
|
4.9
|
44.0
|
1.0
|
CA
|
1:ARG21
|
4.9
|
49.7
|
1.0
|
CA
|
1:PHE39
|
5.0
|
56.5
|
1.0
|
C
|
1:SER36
|
5.0
|
45.5
|
1.0
|
|
Cadmium binding site 5 out
of 5 in 3i55
Go back to
Cadmium Binding Sites List in 3i55
Cadmium binding site 5 out
of 5 in the Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit
Mono view
Stereo pair view
|
A full contact list of Cadmium with other atoms in the Cd binding
site number 5 of Co-Crystal Structure of Mycalamide A Bound to the Large Ribosomal Subunit within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
3:Cd8704
b:0.0
occ:1.00
|
CB
|
3:CYS11
|
3.5
|
0.6
|
1.0
|
CB
|
3:CYS14
|
3.9
|
0.7
|
1.0
|
N
|
3:CYS14
|
4.0
|
0.3
|
1.0
|
SG
|
3:CYS14
|
4.2
|
0.1
|
1.0
|
SG
|
3:CYS11
|
4.2
|
0.6
|
1.0
|
CE1
|
3:HIS20
|
4.2
|
0.4
|
1.0
|
CB
|
3:HIS13
|
4.4
|
0.2
|
1.0
|
O
|
3:CYS11
|
4.4
|
0.9
|
1.0
|
SG
|
3:CYS71
|
4.5
|
0.9
|
1.0
|
CA
|
3:CYS14
|
4.5
|
0.6
|
1.0
|
CA
|
3:CYS11
|
4.5
|
0.7
|
1.0
|
NE2
|
3:HIS20
|
4.5
|
0.3
|
1.0
|
CG
|
3:GLU16
|
4.7
|
0.5
|
1.0
|
N
|
3:CYS11
|
4.7
|
0.7
|
1.0
|
C
|
3:CYS11
|
4.8
|
0.0
|
1.0
|
NE2
|
3:GLN18
|
4.8
|
0.7
|
1.0
|
O
|
3:GLU16
|
4.9
|
0.6
|
1.0
|
C
|
3:HIS13
|
5.0
|
1.0
|
1.0
|
OE1
|
3:GLU16
|
5.0
|
0.5
|
1.0
|
|
Reference:
G.Gurel,
G.Blaha,
T.A.Steitz,
P.B.Moore.
Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula Marismortui. Antimicrob.Agents Chemother. V. 53 5010 2009.
ISSN: ISSN 0066-4804
PubMed: 19738021
DOI: 10.1128/AAC.00817-09
Page generated: Fri Jul 19 16:06:05 2024
|