Cadmium in PDB 4bw5: Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1), PDB code: 4bw5 was solved by A.C.W.Pike, Y.Y.Dong, L.Dong, A.Quigley, L.Shrestha, S.Mukhopadhyay, C.Strain-Damerell, S.Goubin, M.Grieben, C.A.Shintre, A.Mackenzie, M.Vollmar, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, N.Burgess-Brown, E.P.Carpenter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.57 / 3.20
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	87.830, 96.960, 103.700, 90.00, 92.58, 90.00
R / Rfree (%)	23.7 / 25.4

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) also contains other interesting chemical elements:

Potassium

(K)

8 atoms

The binding sites of Cadmium atom in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) (pdb code 4bw5). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1), PDB code: 4bw5:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd701 b:0.1 occ:1.00 OE2 B:GLU116 2.1 0.4 1.0 OE1 B:GLU113 2.2 0.0 1.0 OD1 D:ASP120 2.4 0.8 1.0 OD2 D:ASP120 2.5 0.8 1.0 OE2 B:GLU113 2.6 0.9 1.0 CD B:GLU113 2.7 0.5 1.0 CG D:ASP120 2.7 0.2 1.0 CD B:GLU116 3.2 0.3 1.0 NH2 D:ARG119 3.6 0.2 1.0 OE1 B:GLU116 4.0 0.8 1.0 CG B:GLU116 4.1 0.1 1.0 CE1 A:HIS135 4.1 0.4 1.0 CG B:GLU113 4.2 0.5 1.0 CB D:ASP120 4.3 0.2 1.0 OE2 D:GLU116 4.4 0.8 1.0 CG D:GLU116 4.5 0.4 1.0 CZ D:ARG119 4.5 0.3 1.0 NE2 A:HIS135 4.6 0.9 1.0 NE D:ARG119 4.7 0.7 1.0 CD D:GLU116 5.0 0.5 1.0 ND1 A:HIS135 5.0 1.0 1.0

Cadmium binding site 2 out of 2 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd702 b:0.4 occ:1.00 OD1 B:ASP120 2.2 0.7 1.0 OE1 D:GLU116 2.2 0.5 1.0 OE1 D:GLU113 2.4 0.9 1.0 OE2 D:GLU113 2.5 0.9 1.0 CD D:GLU113 2.8 1.0 1.0 OD2 B:ASP120 2.8 0.6 1.0 CG B:ASP120 2.8 0.8 1.0 CD D:GLU116 3.2 0.5 1.0 OE2 D:GLU116 3.6 0.8 1.0 NH2 B:ARG119 4.1 0.7 1.0 OE1 B:GLU116 4.2 0.8 1.0 CE1 C:HIS135 4.2 0.8 1.0 CG D:GLU113 4.3 0.7 1.0 CB B:ASP120 4.3 0.0 1.0 CG D:GLU116 4.4 0.4 1.0 NE2 C:HIS135 4.5 0.1 1.0 O B:GLU116 4.8 1.0 1.0 NE B:ARG119 4.9 0.1 1.0 CZ B:ARG119 4.9 0.3 1.0 CA B:ASP120 4.9 0.2 1.0 CB D:GLU116 5.0 0.3 1.0

A.C.W.Pike, A.Mackenzie, C.Mcclenaghan, P.Aryal, L.Dong, A.Quigley, M.Grieben, S.Goubin, S.Mukhopadhyay, G.F.Ruda, M.V.Clausen, L.Cao, P.E.Brennan, N.A.Burgess-Brown, M.S.P.Sansom, S.J.Tucker, E.P.Carpenter. K2P Channel Gating Mechanisms Revealed By Structures of Trek-2 and A Complex with Prozac Science V. 347 1256 2015.
ISSN: ISSN 0036-8075
PubMed: 25766236
DOI: 10.1126/SCIENCE.1261512