Cadmium in PDB 4fvg: Spfh Domain of Mouse Stomatin (Crystal Form 3)

The structure of Spfh Domain of Mouse Stomatin (Crystal Form 3), PDB code: 4fvg was solved by J.Brand, D.Schwefel, O.Daumke, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	73.17 / 1.80
Space group	P 64 2 2
Cell size a, b, c (Å), α, β, γ (°)	84.489, 84.489, 68.937, 90.00, 90.00, 120.00
R / Rfree (%)	19.4 / 24.5

The binding sites of Cadmium atom in the Spfh Domain of Mouse Stomatin (Crystal Form 3) (pdb code 4fvg). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Spfh Domain of Mouse Stomatin (Crystal Form 3), PDB code: 4fvg:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Spfh Domain of Mouse Stomatin (Crystal Form 3)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Spfh Domain of Mouse Stomatin (Crystal Form 3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd301 b:34.7 occ:0.45 OE2 A:GLU169 2.0 57.8 0.7 OE1 A:GLU169 2.1 60.0 0.7 CD A:GLU169 2.1 57.4 0.7 NE2 A:HIS173 2.5 40.8 0.7 ND1 A:HIS172 2.6 33.9 0.5 CE1 A:HIS172 2.9 29.7 0.5 CD2 A:HIS173 3.4 36.8 0.7 CG A:GLU169 3.4 48.4 1.0 CE1 A:HIS173 3.5 42.9 0.7 CD A:CD302 3.6 35.9 0.4 CG A:HIS172 3.6 33.1 0.5 O A:HOH488 3.7 30.2 1.0 NE2 A:HIS172 3.9 30.8 0.5 O A:HOH436 4.2 19.0 1.0 CD2 A:HIS172 4.3 37.1 0.5 CB A:HIS172 4.3 30.7 0.5 CG A:HIS173 4.5 31.8 0.7 CB A:GLU169 4.5 42.1 1.0 ND1 A:HIS173 4.6 37.3 0.7 CA A:GLU169 4.8 39.2 1.0 O A:HOH435 4.8 15.8 1.0 CB A:HIS172 4.9 29.5 0.5 O A:GLU169 5.0 37.5 1.0

Cadmium binding site 2 out of 2 in the Spfh Domain of Mouse Stomatin (Crystal Form 3)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Spfh Domain of Mouse Stomatin (Crystal Form 3) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd302 b:35.9 occ:0.40 ND1 A:HIS172 2.1 33.9 0.5 O A:HOH488 2.3 30.2 1.0 ND1 A:HIS172 2.3 36.3 0.5 O A:HOH436 2.7 19.0 1.0 OE2 A:GLU169 3.0 57.8 0.7 CG A:HIS172 3.0 33.1 0.5 CE1 A:HIS172 3.0 29.7 0.5 CE1 A:HIS172 3.2 36.8 0.5 CG A:HIS172 3.3 33.2 0.5 CB A:HIS172 3.4 30.7 0.5 CD A:CD301 3.6 34.7 0.5 CB A:HIS172 3.6 29.5 0.5 CD2 A:HIS172 4.0 37.1 0.5 NE2 A:HIS172 4.0 30.8 0.5 CD A:GLU169 4.1 57.4 0.7 NE2 A:HIS172 4.3 35.5 0.5 CD2 A:HIS172 4.4 34.9 0.5 OE1 A:GLU169 4.6 60.0 0.7 CA A:HIS172 4.9 28.1 0.5 CA A:GLU169 4.9 39.2 1.0

J.Brand, E.S.Smith, D.Schwefel, L.Lapatsina, K.Poole, D.Omerbasic, A.Kozlenkov, J.Behlke, G.R.Lewin, O.Daumke. A Stomatin Dimer Modulates the Activity of Acid-Sensing Ion Channels. Embo J. V. 31 3635 2012.
ISSN: ISSN 0261-4189
PubMed: 22850675
DOI: 10.1038/EMBOJ.2012.203