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Cadmium in PDB 4mvs: Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel

Protein crystallography data

The structure of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvs was solved by L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 3.30
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 178.590, 178.650, 131.135, 90.00, 132.89, 90.00
R / Rfree (%) 23.3 / 26.9

Cadmium Binding Sites:

The binding sites of Cadmium atom in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel (pdb code 4mvs). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 5 binding sites of Cadmium where determined in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel, PDB code: 4mvs:
Jump to Cadmium binding site number: 1; 2; 3; 4; 5;

Cadmium binding site 1 out of 5 in 4mvs

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Cadmium binding site 1 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cd1301

b:52.5
occ:1.00
O A:HOH1401 2.2 35.0 1.0
O B:HOH1401 2.2 39.2 1.0
O D:HOH1401 2.2 30.6 1.0
O C:HOH1402 2.3 75.3 1.0
O C:HOH1401 2.3 23.9 1.0
O D:HOH1402 2.5 28.9 1.0
N B:ASP1178 4.2 57.9 1.0
N D:ASP1178 4.3 56.7 1.0
N A:ASP1178 4.3 53.4 1.0
N C:ASP1178 4.4 55.5 1.0
OD1 A:ASP1177 4.6 71.4 1.0
O B:LEU1176 4.6 52.8 1.0
OD1 B:ASP1177 4.7 65.8 1.0
O D:LEU1176 4.7 43.1 1.0
O C:LEU1176 4.7 39.9 1.0
OD1 C:ASP1177 4.8 61.5 1.0
O A:LEU1176 4.8 47.4 1.0
OD1 D:ASP1177 4.8 64.2 1.0
CA B:ASP1177 4.9 54.8 1.0
CA A:ASP1177 5.0 54.5 1.0

Cadmium binding site 2 out of 5 in 4mvs

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Cadmium binding site 2 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Cd1302

b:0.6
occ:1.00
OE2 A:GLU1165 2.7 78.1 1.0
O A:PRO1157 2.8 75.3 1.0
OE1 A:GLU1165 2.8 90.6 1.0
CD A:GLU1165 3.1 73.8 1.0
C A:PRO1157 3.6 61.9 1.0
CA A:GLY1161 4.0 58.6 1.0
CB A:PRO1157 4.0 61.9 1.0
CA A:PRO1157 4.2 60.4 1.0
C A:GLY1161 4.3 60.5 1.0
N A:GLU1158 4.5 63.7 1.0
N A:THR1162 4.5 69.4 1.0
CG A:GLU1165 4.5 75.9 1.0
N A:GLY1161 4.6 51.1 1.0
CA A:GLU1158 4.6 63.0 1.0
CB A:THR1162 4.7 67.2 1.0
O A:GLU1158 4.9 63.9 1.0
OG1 A:THR1162 4.9 70.5 1.0
O A:GLY1161 4.9 63.3 1.0
C A:GLU1158 5.0 53.8 1.0

Cadmium binding site 3 out of 5 in 4mvs

Go back to Cadmium Binding Sites List in 4mvs
Cadmium binding site 3 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Cd1301

b:0.4
occ:1.00
OE2 B:GLU1165 2.7 0.5 1.0
O B:PRO1157 2.7 62.7 1.0
OE1 B:GLU1165 2.8 98.4 1.0
CD B:GLU1165 3.1 84.9 1.0
C B:PRO1157 3.6 58.4 1.0
CA B:GLY1161 3.9 67.5 1.0
CB B:PRO1157 4.0 53.1 1.0
C B:GLY1161 4.2 69.4 1.0
CA B:PRO1157 4.3 53.4 1.0
N B:GLY1161 4.5 54.5 1.0
N B:THR1162 4.5 75.3 1.0
CG B:GLU1165 4.5 78.6 1.0
N B:GLU1158 4.5 67.7 1.0
OG1 B:THR1162 4.7 56.1 1.0
CA B:GLU1158 4.7 68.1 1.0
CB B:THR1162 4.7 58.7 1.0
O B:GLY1161 4.8 72.4 1.0

Cadmium binding site 4 out of 5 in 4mvs

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Cadmium binding site 4 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 4 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Cd1301

b:0.5
occ:1.00
OE1 C:GLU1165 2.5 0.2 1.0
OE2 C:GLU1165 2.7 90.5 1.0
O C:PRO1157 2.8 72.4 1.0
CD C:GLU1165 2.9 81.2 1.0
C C:PRO1157 3.8 66.2 1.0
CA C:GLY1161 4.3 63.1 1.0
CB C:PRO1157 4.3 59.8 1.0
CG C:GLU1165 4.4 79.6 1.0
CA C:PRO1157 4.5 58.1 1.0
C C:GLY1161 4.5 61.4 1.0
N C:GLU1158 4.6 69.8 1.0
N C:THR1162 4.7 69.4 1.0
CA C:GLU1158 4.7 74.4 1.0
CB C:THR1162 4.7 58.8 1.0
N C:GLY1161 4.8 54.8 1.0
OG1 C:THR1162 5.0 60.7 1.0

Cadmium binding site 5 out of 5 in 4mvs

Go back to Cadmium Binding Sites List in 4mvs
Cadmium binding site 5 out of 5 in the Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 5 of Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Cd1301

b:0.0
occ:1.00
O D:PRO1157 2.7 61.7 1.0
OE2 D:GLU1165 2.7 72.4 1.0
OE1 D:GLU1165 2.8 77.9 1.0
CD D:GLU1165 3.1 68.4 1.0
C D:PRO1157 3.5 63.0 1.0
CB D:PRO1157 4.0 53.0 1.0
CA D:PRO1157 4.2 54.6 1.0
CA D:GLY1161 4.2 61.2 1.0
N D:GLU1158 4.4 67.5 1.0
CA D:GLU1158 4.5 60.8 1.0
CG D:GLU1165 4.5 68.1 1.0
C D:GLY1161 4.6 65.0 1.0
N D:GLY1161 4.6 50.2 1.0
N D:THR1162 4.7 73.5 1.0
C D:GLU1158 4.9 52.4 1.0
CB D:THR1162 4.9 64.6 1.0
O D:GLU1158 4.9 60.7 1.0

Reference:

L.Tang, T.M.Gamal El-Din, J.Payandeh, G.Q.Martinez, T.M.Heard, T.Scheuer, N.Zheng, W.A.Catterall. Structural Basis For CA2+ Selectivity of A Voltage-Gated Calcium Channel. Nature V. 505 56 2014.
ISSN: ISSN 0028-0836
PubMed: 24270805
DOI: 10.1038/NATURE12775
Page generated: Sat Dec 12 08:25:13 2020

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