Cadmium in PDB 6cq6: K2P2.1(Trek-1) Apo Structure

The structure of K2P2.1(Trek-1) Apo Structure, PDB code: 6cq6 was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.97 / 3.10
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.718, 120.417, 126.440, 90.00, 90.00, 90.00
R / Rfree (%)	26 / 30.2

The structure of K2P2.1(Trek-1) Apo Structure also contains other interesting chemical elements:

Potassium

(K)

6 atoms

The binding sites of Cadmium atom in the K2P2.1(Trek-1) Apo Structure (pdb code 6cq6). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the K2P2.1(Trek-1) Apo Structure, PDB code: 6cq6:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of K2P2.1(Trek-1) Apo Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd401 b:0.1 occ:1.00 OE1 A:GLU309 2.8 0.3 1.0 CD A:GLU309 3.8 0.8 1.0 NE2 A:HIS313 4.1 0.5 1.0 OE2 A:GLU309 4.4 0.5 1.0 CG A:GLU309 4.7 0.1 1.0 CE1 A:HIS313 4.8 0.5 1.0

Cadmium binding site 2 out of 3 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of K2P2.1(Trek-1) Apo Structure within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd402 b:0.1 occ:1.00 OE1 B:GLU309 2.6 0.2 1.0 NE2 B:HIS313 2.8 0.9 1.0 OE2 B:GLU309 2.9 0.6 1.0 CD B:GLU309 3.1 1.0 1.0 CE1 B:HIS313 3.3 0.9 1.0 CD2 B:HIS313 3.8 0.7 1.0 ND1 B:HIS313 4.4 0.9 1.0 CG B:GLU309 4.5 0.3 1.0 CG B:HIS313 4.7 0.8 1.0 CB B:ALA312 5.0 0.5 1.0

Cadmium binding site 3 out of 3 in the K2P2.1(Trek-1) Apo Structure


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of K2P2.1(Trek-1) Apo Structure within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd403 b:1.0 occ:1.00 OD2 B:ASP263 3.0 0.3 1.0 CE1 B:HIS126 3.1 0.8 1.0 NE2 B:HIS126 3.1 0.5 1.0 OD1 B:ASP263 3.5 0.1 1.0 CG B:ASP263 3.6 0.1 1.0 CD1 B:ILE115 3.8 0.9 1.0 CG1 B:ILE115 4.2 0.7 1.0 ND1 B:HIS126 4.3 0.3 1.0 CD2 B:HIS126 4.4 0.6 1.0

M.Lolicato, C.Arrigoni, T.Mori, Y.Sekioka, C.Bryant, K.A.Clark, D.L.Minor. K2P2.1 (Trek-1)-Activator Complexes Reveal A Cryptic Selectivity Filter Binding Site. Nature V. 547 364 2017.
ISSN: ESSN 1476-4687
PubMed: 28693035
DOI: 10.1038/NATURE22988