Cadmium in PDB 6ghx: Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin

Enzymatic activity of Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin

All present enzymatic activity of Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin:
3.4.24.27;

Protein crystallography data

The structure of Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin, PDB code: 6ghx was solved by J.P.Leite, L.Gales, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	46.53 / 1.16
*Space group*	P 6₁ 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	93.060, 93.060, 130.290, 90.00, 90.00, 120.00
*R / R_free (%)*	20.2 / 22

Other elements in 6ghx:

The structure of Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

Cadmium Binding Sites:

The binding sites of Cadmium atom in the Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin (pdb code 6ghx). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total only one binding site of Cadmium was determined in the Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin, PDB code: 6ghx:

Cadmium binding site 1 out of 1 in 6ghx

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Cadmium Binding Sites List in 6ghx

Cadmium binding site 1 out of 1 in the Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin

Mono view

Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Alzheimer'S Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd- Substituted Thermolysin within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Cd405 b:19.4 occ:1.00	NE2	A:HIS142	2.3	20.2	1.0
	NE2	A:HIS146	2.3	18.1	1.0
	OE2	A:GLU166	2.3	21.8	1.0
	O	A:HOH509	2.4	21.3	1.0
	O	A:HOH502	2.5	29.2	1.0
	CD	A:GLU166	3.0	20.2	1.0
	OE1	A:GLU166	3.1	18.9	1.0
	CD2	A:HIS142	3.2	19.4	1.0
	CE1	A:HIS146	3.3	17.4	1.0
	CD2	A:HIS146	3.3	18.5	1.0
	CE1	A:HIS142	3.3	18.2	1.0
	OE1	A:GLU143	4.0	25.6	1.0
	N	A:ILE407	4.1	25.4	1.0
	OH	A:TYR157	4.1	21.3	1.0
	NE2	A:HIS231	4.2	21.1	1.0
	CA	A:ILE407	4.3	22.4	1.0
	CG	A:HIS142	4.4	17.4	1.0
	ND1	A:HIS146	4.4	19.4	1.0
	ND1	A:HIS142	4.4	17.9	1.0
	CG	A:GLU166	4.4	16.7	1.0
	CG	A:HIS146	4.4	18.0	1.0
	O	A:HOH720	4.5	27.3	1.0
	OE2	A:GLU143	4.6	32.3	1.0
	CD	A:GLU143	4.6	26.7	1.0
	CB	A:SER169	4.8	16.9	1.0
	CD2	A:HIS231	4.9	20.8	1.0
	C	A:ILE407	4.9	21.7	1.0
	OG	A:SER169	5.0	17.3	1.0

Reference:

J.P.Leite, L.Gales. Alzheimer'S A BETA1-40PEPTIDE Degradation By Thermolysin: Evidence of Inhibition By A C-Terminal A Beta Product. Febs Lett. V. 593 128 2019.
ISSN: ISSN 1873-3468
PubMed: 30403288
DOI: 10.1002/1873-3468.13285

Page generated: Fri Jul 19 19:18:21 2024

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