Cadmium in PDB 6w7c: K2P2.1 (Trek-1), 1 Mm K+

The structure of K2P2.1 (Trek-1), 1 Mm K+, PDB code: 6w7c was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.99 / 3.40
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	66.501, 123.014, 125.848, 90, 90, 90
R / Rfree (%)	28.2 / 28.9

The structure of K2P2.1 (Trek-1), 1 Mm K+ also contains other interesting chemical elements:

Potassium

(K)

3 atoms

The binding sites of Cadmium atom in the K2P2.1 (Trek-1), 1 Mm K+ (pdb code 6w7c). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the K2P2.1 (Trek-1), 1 Mm K+, PDB code: 6w7c:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the K2P2.1 (Trek-1), 1 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of K2P2.1 (Trek-1), 1 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd401 b:198.9 occ:1.00 OE2 A:GLU309 2.7 250.4 1.0 NE2 A:HIS313 2.7 178.9 1.0 CE1 A:HIS313 3.3 177.9 1.0 CD A:GLU309 3.5 247.2 1.0 CG A:GLU309 3.7 198.0 1.0 CD2 A:HIS313 4.0 176.9 1.0 ND1 A:HIS313 4.6 177.4 1.0 OE1 A:GLU309 4.7 268.9 1.0 CG A:HIS313 4.9 174.7 1.0

Cadmium binding site 2 out of 3 in the K2P2.1 (Trek-1), 1 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of K2P2.1 (Trek-1), 1 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd402 b:265.8 occ:0.50 CG2 A:ILE233 3.2 255.2 1.0 CD A:GLU234 3.3 253.8 1.0 OE1 A:GLU234 3.3 273.1 1.0 CB A:ILE233 3.3 254.7 1.0 OE2 A:GLU234 3.6 236.1 1.0 CG A:GLU234 3.7 261.7 1.0 O A:ILE233 3.8 268.6 1.0 C A:ILE233 3.9 264.9 1.0 CA A:ILE233 4.1 264.9 1.0 CB A:GLU234 4.2 267.9 1.0 N A:GLU234 4.5 266.7 1.0 N A:ILE233 4.5 276.4 1.0 CG1 A:ILE233 4.6 248.6 1.0 CD1 A:ILE233 4.8 241.1 1.0

Cadmium binding site 3 out of 3 in the K2P2.1 (Trek-1), 1 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of K2P2.1 (Trek-1), 1 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd401 b:226.9 occ:0.50 NE2 B:HIS126 2.8 186.1 1.0 N B:ILE114 3.0 211.8 1.0 CA B:GLY113 3.3 197.4 1.0 C B:GLY113 3.4 207.0 1.0 O B:ILE114 3.4 236.9 1.0 CD2 B:HIS126 3.5 182.3 1.0 CD1 B:ILE115 3.8 300.0 1.0 C B:ILE114 3.8 238.2 1.0 CE1 B:HIS126 3.9 182.9 1.0 CA B:ILE114 4.0 222.2 1.0 O B:GLY113 4.4 210.0 1.0 CG1 B:ILE115 4.5 300.0 1.0 N B:GLY113 4.7 194.8 1.0 N B:ILE115 4.7 246.8 1.0 CG B:HIS126 4.7 176.0 1.0 ND1 B:HIS126 4.8 179.0 1.0 O B:ALA112 4.9 192.3 1.0

M.Lolicato, A.M.Natale, F.Abderemane-Ali, D.Crottes, S.Capponi, R.Duman, A.Wagner, J.M.Rosenberg, M.Grabe, D.L.Minor Jr.. K 2P Channel C-Type Gating Involves Asymmetric Selectivity Filter Order-Disorder Transitions. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33127683
DOI: 10.1126/SCIADV.ABC9174