Cadmium in PDB 6w83: K2P2.1 (Trek-1), 100 Mm K+

The structure of K2P2.1 (Trek-1), 100 Mm K+, PDB code: 6w83 was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.95 / 3.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	70.222, 121.164, 129.426, 90, 90, 90
R / Rfree (%)	24.2 / 31.2

The structure of K2P2.1 (Trek-1), 100 Mm K+ also contains other interesting chemical elements:

Potassium

(K)

6 atoms

The binding sites of Cadmium atom in the K2P2.1 (Trek-1), 100 Mm K+ (pdb code 6w83). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the K2P2.1 (Trek-1), 100 Mm K+, PDB code: 6w83:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the K2P2.1 (Trek-1), 100 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of K2P2.1 (Trek-1), 100 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd401 b:170.1 occ:1.00 OE1 A:GLU309 3.0 197.8 1.0 OE2 A:GLU309 3.2 246.1 1.0 NE2 A:HIS313 3.2 223.5 1.0 CD A:GLU309 3.4 245.7 1.0 CE1 A:HIS313 3.5 220.2 1.0 CD2 A:HIS313 4.4 215.0 1.0 ND1 A:HIS313 4.6 204.7 1.0 CG A:GLU309 4.8 257.4 1.0

Cadmium binding site 2 out of 3 in the K2P2.1 (Trek-1), 100 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of K2P2.1 (Trek-1), 100 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd402 b:188.9 occ:0.50 OD2 A:ASP263 3.4 267.8 1.0 CE1 A:HIS126 3.4 203.5 1.0 NE2 A:HIS126 3.5 193.4 1.0 OD1 A:ASP263 3.7 298.3 1.0 CG A:ASP263 3.8 298.0 1.0 ND1 A:HIS126 4.3 234.7 1.0 CD2 A:HIS126 4.4 196.2 1.0 CG A:HIS126 4.8 218.5 1.0

Cadmium binding site 3 out of 3 in the K2P2.1 (Trek-1), 100 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of K2P2.1 (Trek-1), 100 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd401 b:221.3 occ:1.00 CE1 B:HIS126 2.8 228.1 1.0 OD2 B:ASP263 2.8 240.1 1.0 NE2 B:HIS126 3.1 243.2 1.0 OD1 B:ASP263 3.3 212.6 1.0 CG B:ASP263 3.4 241.5 1.0 CD1 B:ILE115 3.5 299.3 1.0 ND1 B:HIS126 4.0 218.9 1.0 CG1 B:ILE115 4.1 299.3 1.0 CD2 B:HIS126 4.3 242.0 1.0 O B:ILE114 4.4 289.4 1.0 CG B:HIS126 4.8 238.8 1.0 CB B:ASP263 4.9 258.1 1.0

M.Lolicato, A.M.Natale, F.Abderemane-Ali, D.Crottes, S.Capponi, R.Duman, A.Wagner, J.M.Rosenberg, M.Grabe, D.L.Minor Jr.. K 2P Channel C-Type Gating Involves Asymmetric Selectivity Filter Order-Disorder Transitions. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33127683
DOI: 10.1126/SCIADV.ABC9174