Cadmium in PDB 6w8c: K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+

The structure of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+, PDB code: 6w8c was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.97 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.129, 119.783, 128.872, 90, 90, 90
R / Rfree (%)	25.1 / 26.3

The structure of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ also contains other interesting chemical elements:

Potassium	(K)	6 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Cadmium atom in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ (pdb code 6w8c). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+, PDB code: 6w8c:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd402 b:203.0 occ:1.00 CE1 B:HIS126 2.9 143.3 1.0 OD1 B:ASP263 3.1 153.1 1.0 NE2 B:HIS126 3.6 140.2 1.0 OD2 B:ASP263 3.7 157.5 1.0 CG B:ASP263 3.8 153.4 1.0 ND1 B:HIS126 3.9 142.3 1.0 CD1 B:ILE115 4.4 204.1 1.0 CD2 B:HIS126 4.7 137.3 1.0 CG B:HIS126 4.9 136.5 1.0 O B:GLY113 4.9 176.7 1.0 CG1 B:ILE115 4.9 196.3 1.0 O05 B:Q6F415 5.0 106.2 1.0

Cadmium binding site 2 out of 3 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd403 b:124.1 occ:1.00 OE1 B:GLU309 2.1 132.9 1.0 NE2 B:HIS313 2.3 91.7 1.0 CD B:GLU309 2.8 132.0 1.0 CE1 B:HIS313 2.9 91.9 1.0 OE2 B:GLU309 2.9 138.3 1.0 CD2 B:HIS313 3.5 93.0 1.0 ND1 B:HIS313 4.1 93.6 1.0 CG B:GLU309 4.3 117.2 1.0 CG B:HIS313 4.4 97.5 1.0 CB B:GLU309 4.8 111.4 1.0 CA B:GLU309 4.9 108.6 1.0

Cadmium binding site 3 out of 3 in the K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of K2P2.1 (Trek-1):ML335 Complex, 1 Mm K+ within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd404 b:176.6 occ:1.00 OD2 B:ASP128 2.3 127.4 1.0 CG B:ASP128 3.2 125.0 1.0 OD1 B:ASP128 3.3 126.6 1.0 OG B:SER131 4.0 89.8 1.0 N B:SER131 4.1 91.4 1.0 CA B:GLY130 4.5 101.0 1.0 CB B:ASP128 4.6 115.5 1.0 C B:GLY130 4.7 94.5 1.0 N B:GLY130 4.8 105.3 1.0 CB B:SER131 4.8 89.4 1.0 NZ B:LYS271 4.8 90.6 1.0 CA B:SER131 5.0 89.2 1.0

M.Lolicato, A.M.Natale, F.Abderemane-Ali, D.Crottes, S.Capponi, R.Duman, A.Wagner, J.M.Rosenberg, M.Grabe, D.L.Minor Jr.. K 2P Channel C-Type Gating Involves Asymmetric Selectivity Filter Order-Disorder Transitions. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33127683
DOI: 10.1126/SCIADV.ABC9174