Cadmium in PDB 7b29: Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus

The structure of Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus, PDB code: 7b29 was solved by S.M.Lea, S.Johnson, K.Braunger, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.90 / 1.83
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	40.12, 54.33, 79.73, 90, 90, 90
R / Rfree (%)	19.2 / 23.6

The structure of Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Cadmium atom in the Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus (pdb code 7b29). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus, PDB code: 7b29:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd301 b:24.7 occ:1.00 NE2 A:HIS110 2.4 24.3 1.0 O A:HOH504 2.6 27.4 1.0 CD2 A:HIS110 3.2 23.9 1.0 CE1 A:HIS110 3.5 26.9 1.0 OH A:TYR118 4.1 35.9 1.0 CE1 A:TYR118 4.3 27.3 1.0 O A:LYS115 4.4 32.0 1.0 CG A:HIS110 4.4 22.4 1.0 ND1 A:HIS110 4.6 21.9 1.0 CZ A:TYR118 4.6 31.5 1.0 O A:HOH523 4.7 35.4 1.0

Cadmium binding site 2 out of 3 in the Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd302 b:30.1 occ:1.00 OE1 A:GLU129 2.6 35.3 1.0 OE2 A:GLU129 2.7 37.5 1.0 O A:HOH512 2.7 43.8 1.0 O A:HOH416 2.9 55.1 1.0 CD A:GLU129 3.0 39.3 1.0 NH1 A:ARG152 4.2 45.8 1.0 CG A:GLU129 4.5 37.2 1.0 NH2 A:ARG152 4.9 45.5 1.0

Cadmium binding site 3 out of 3 in the Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of Complement Inhibitor CIRPA4 From Rhipicephalus Appendiculatus within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd303 b:149.5 occ:1.00 NE2 A:HIS80 2.9 47.2 1.0 CD2 A:HIS80 3.6 45.5 1.0 CE1 A:HIS80 4.0 44.4 1.0 CG A:HIS80 4.9 40.8 1.0 OD1 A:ASN81 4.9 54.1 1.0 ND1 A:HIS80 5.0 44.6 1.0

S.M.Lea, S.Johnson, K.Braunger, M.M.Jore, J.Ahn, T.Tang, D.V.Pedersen, G.R.Andersen. Targeting Properdin - Structure and Function of A Novel Family of Tick-Derived Complement Inhibitors To Be Published.