Cadmium in PDB 8ap5: Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2

The binding sites of Cadmium atom in the Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2 (pdb code 8ap5). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2, PDB code: 8ap5:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd101 b:74.5 occ:1.00 HB2 A:CYS58 2.5 1.5 1.0 SG A:CYS33 2.5 43.2 1.0 SG A:CYS58 2.5 14.1 1.0 SG A:CYS51 2.5 64.1 1.0 SG A:CYS34 2.6 4.2 1.0 CB A:CYS58 3.0 65.2 1.0 H A:CYS51 3.1 33.2 1.0 HB3 A:CYS33 3.1 13.6 1.0 CB A:CYS33 3.5 73.1 1.0 HB3 A:CYS58 3.7 33.2 1.0 CD A:CD102 3.9 51.5 1.0 CB A:CYS34 4.0 3.3 1.0 HB3 A:CYS34 4.0 65.1 1.0 SG A:CYS56 4.0 43.3 1.0 N A:CYS51 4.1 23.3 1.0 H A:CYS34 4.1 22.4 1.0 H A:GLY50 4.2 64.3 1.0 CB A:CYS51 4.2 72.5 1.0 HB2 A:CYS33 4.2 22.5 1.0 N A:CYS34 4.2 65.1 1.0 CA A:CYS58 4.2 61.3 1.0 HA A:CYS58 4.2 41.1 1.0 CD A:CD103 4.2 31.2 1.0 H A:CYS58 4.3 62.5 1.0 C A:CYS33 4.4 70.4 1.0 HB3 A:CYS51 4.4 42.0 1.0 HA2 A:GLY50 4.4 41.3 1.0 H A:LYS52 4.5 61.0 1.0 HB3 A:CYS47 4.5 22.4 1.0 CA A:CYS33 4.6 55.4 1.0 N A:GLY50 4.6 61.0 1.0 N A:CYS58 4.6 32.3 1.0 CA A:CYS34 4.7 15.5 1.0 CA A:CYS51 4.7 25.5 1.0 HB2 A:CYS47 4.7 72.3 1.0 HB2 A:CYS34 4.8 75.4 1.0 CA A:GLY50 4.9 23.5 1.0 HA2 A:GLY49 4.9 33.4 1.0 HB2 A:CYS51 4.9 3.1 1.0 SG A:CYS43 4.9 54.4 1.0 O A:CYS33 4.9 54.0 1.0 HA A:CYS34 5.0 25.0 1.0 C A:GLY50 5.0 11.1 1.0

Cadmium binding site 2 out of 3 in the Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd102 b:51.5 occ:1.00 HB2 A:CYS56 2.2 42.5 1.0 HB3 A:CYS56 2.4 12.1 1.0 CB A:CYS56 2.5 24.5 1.0 SG A:CYS43 2.6 54.4 1.0 SG A:CYS34 2.6 4.2 1.0 SG A:CYS56 2.6 43.3 1.0 SG A:CYS42 2.6 3.1 1.0 HB3 A:ALA37 3.0 54.4 1.0 HB3 A:CYS43 3.2 10.3 1.0 HB1 A:ALA37 3.5 41.2 1.0 CB A:CYS43 3.5 32.3 1.0 CB A:ALA37 3.7 11.0 1.0 HB2 A:CYS58 3.8 1.5 1.0 HB2 A:CYS34 3.9 75.4 1.0 H A:GLU57 3.9 53.2 1.0 CD A:CD101 3.9 74.5 1.0 CB A:CYS34 4.0 3.3 1.0 H A:CYS58 4.0 62.5 1.0 CA A:CYS56 4.0 42.5 1.0 HB2 A:CYS53 4.0 43.4 1.0 CD A:CD103 4.0 31.2 1.0 H A:CYS34 4.1 22.4 1.0 CB A:CYS42 4.1 62.2 1.0 H A:CYS43 4.2 20.2 1.0 N A:CYS43 4.2 52.2 1.0 HB2 A:CYS42 4.2 55.0 1.0 HB2 A:CYS43 4.2 4.0 1.0 HB A:THR36 4.4 44.3 1.0 HA A:CYS56 4.4 5.4 1.0 HB2 A:ALA37 4.5 62.3 1.0 CA A:CYS43 4.5 63.1 1.0 N A:GLU57 4.5 30.5 1.0 C A:CYS42 4.5 65.2 1.0 HB3 A:CYS33 4.6 13.6 1.0 HB3 A:CYS34 4.7 65.1 1.0 C A:CYS56 4.7 72.1 1.0 H A:CYS56 4.7 31.2 1.0 CA A:ALA37 4.7 34.4 1.0 SG A:CYS51 4.7 64.1 1.0 N A:CYS34 4.7 65.1 1.0 N A:ALA37 4.8 71.0 1.0 HA A:ALA37 4.8 71.5 1.0 N A:CYS56 4.8 34.2 1.0 CB A:CYS58 4.9 65.2 1.0 HB3 A:CYS42 4.9 11.5 1.0 CA A:CYS42 4.9 2.0 1.0 CA A:CYS34 4.9 15.5 1.0 N A:CYS58 4.9 32.3 1.0 C A:THR36 4.9 1.2 1.0 CB A:CYS53 5.0 71.3 1.0

Cadmium binding site 3 out of 3 in the Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of Cadmium-Loaded Form of Caenorhabditis Elegans Mtl-2 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd103 b:31.2 occ:1.00 HB2 A:CYS43 2.4 4.0 1.0 SG A:CYS51 2.6 64.1 1.0 SG A:CYS47 2.6 1.4 1.0 SG A:CYS53 2.6 52.2 1.0 SG A:CYS43 2.6 54.4 1.0 CB A:CYS43 2.9 32.3 1.0 HB2 A:CYS51 3.0 3.1 1.0 CB A:CYS51 3.1 72.5 1.0 HB3 A:CYS51 3.2 42.0 1.0 HB3 A:CYS43 3.3 10.3 1.0 HB2 A:CYS53 3.6 43.4 1.0 CB A:CYS47 3.7 55.5 1.0 HB2 A:CYS47 3.8 72.3 1.0 CB A:CYS53 3.8 71.3 1.0 H A:CYS53 3.8 74.2 1.0 HG3 A:LYS44 3.8 2.0 1.0 HB3 A:CYS47 3.8 22.4 1.0 H A:LYS52 4.0 61.0 1.0 CD A:CD102 4.0 51.5 1.0 HB3 A:CYS33 4.1 13.6 1.0 O A:LYS44 4.2 71.5 1.0 CD A:CD101 4.2 74.5 1.0 CA A:CYS43 4.3 63.1 1.0 H A:LYS44 4.4 0.1 1.0 HB3 A:CYS53 4.5 42.3 1.0 SG A:CYS56 4.5 43.3 1.0 N A:CYS53 4.5 44.3 1.0 C A:CYS43 4.6 61.0 1.0 N A:LYS44 4.6 21.4 1.0 CA A:CYS51 4.6 25.5 1.0 N A:LYS52 4.8 2.2 1.0 CA A:CYS53 4.8 63.3 1.0 CG A:LYS44 4.8 10.1 1.0 H A:CYS51 4.9 33.2 1.0 HA A:CYS43 4.9 32.0 1.0 HE2 A:LYS44 4.9 42.5 1.0 HG2 A:LYS44 4.9 61.3 1.0

Y.J.Essig, O.I.Leszczyszyn, N.Almutairi, A.Harrison-Smith, A.Blease, S.Zeitoun-Ghandour, S.M.Webb, C.A.Blindauer, S.R.Sturzenbaum. Juggling Cadmium Detoxification and Zinc Homeostasis: A Division of Labour Between the Two C. Elegans Metallothioneins. Chemosphere V. 350 41021 2023.
ISSN: ISSN 1879-1298
PubMed: 38151062
DOI: 10.1016/J.CHEMOSPHERE.2023.141021