Cadmium in PDB 9fum: Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435

The structure of Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435, PDB code: 9fum was solved by S.Narasimhan, S.Jansen, L.Zidek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.83 / 2.45
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	74.394, 69.137, 82.797, 90, 112, 90
R / Rfree (%)	21 / 27.5

The binding sites of Cadmium atom in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435 (pdb code 9fum). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 5 binding sites of Cadmium where determined in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435, PDB code: 9fum:
Jump to Cadmium binding site number: 1; 2; 3; 4; 5;

Cadmium binding site 1 out of 5 in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd301 b:47.2 occ:1.00 OE1 A:GLU73 2.0 35.2 1.0 OE2 A:GLU76 2.2 39.1 1.0 OE1 A:GLN79 2.5 51.5 1.0 OE1 A:GLU76 2.6 41.3 1.0 CD A:GLU76 2.7 47.0 1.0 CD A:GLU73 3.0 43.4 1.0 CD A:GLN79 3.3 44.4 1.0 OE2 A:GLU73 3.4 53.4 1.0 NE2 A:GLN79 3.5 48.3 1.0 CG A:GLU76 4.2 45.6 1.0 CG A:GLU73 4.3 48.4 1.0 CA A:GLU73 4.7 47.0 1.0 CG A:GLN79 4.7 43.1 1.0 N A:GLY74 4.8 40.9 1.0 O A:HOH407 4.9 45.3 1.0

Cadmium binding site 2 out of 5 in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435 within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd302 b:45.3 occ:1.00 OE2 A:GLU87 2.1 51.4 1.0 OE2 A:GLU84 2.5 50.1 1.0 OE1 A:GLU84 2.6 45.8 1.0 CD A:GLU84 2.8 53.4 1.0 CD A:GLU87 2.8 54.5 1.0 OE1 A:GLU87 2.9 52.4 1.0 CG A:GLU87 4.3 50.4 1.0 CG A:GLU84 4.3 50.5 1.0 CA A:GLU84 4.9 42.1 1.0

Cadmium binding site 3 out of 5 in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd301 b:48.7 occ:1.00 OE2 B:GLU105 2.3 37.9 1.0 OE1 B:GLU105 2.4 40.1 1.0 CD B:GLU105 2.6 46.3 1.0 O B:HOH462 3.9 54.1 1.0 CG B:GLU105 4.2 38.4 1.0 CB B:GLU105 5.0 38.5 1.0

Cadmium binding site 4 out of 5 in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 4 of Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd302 b:111.1 occ:1.00 OD2 B:ASP146 2.6 74.0 1.0 CG B:ASP146 3.5 67.7 1.0 OD1 B:ASP146 3.7 83.4 1.0 O B:HOH477 4.6 48.7 1.0 CB B:ASP146 4.9 55.1 1.0

Cadmium binding site 5 out of 5 in the Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 5 of Dimeric 14-3-3 Zeta in Complex with MAP2C Peptide Containing PS435 within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd303 b:44.6 occ:1.00 OE1 B:GLU84 2.2 32.0 1.0 OE1 B:GLU87 2.2 56.6 1.0 OE2 B:GLU84 2.8 39.4 1.0 CD B:GLU84 2.8 34.7 1.0 OE2 B:GLU87 2.8 61.0 1.0 CD B:GLU87 2.9 60.7 1.0 OE1 B:GLN80 4.1 64.3 1.0 CG B:GLU84 4.3 34.3 1.0 CG B:GLU87 4.4 48.6 1.0 O B:HOH413 4.7 60.7 1.0 CA B:GLU84 4.7 38.5 1.0 CG B:ARG83 4.8 44.6 1.0 CD B:ARG83 4.8 44.9 1.0 CB B:GLU87 5.0 43.7 1.0

S.Jansen, S.Narasimhan, P.Cabre Fernandez, L.Ilkovicova, A.Kozelekova, K.Kralova, J.Hritz, L.Zidek. Characterization of Multiple Binding Sites on Microtubule Associated Protein 2C Recognized By Dimeric and Monomeric 14-3-3 Zeta. Febs J. 2025.
ISSN: ISSN 1742-464X
PubMed: 39877981
DOI: 10.1111/FEBS.17405