Cadmium in PDB 4zp3: AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka

The structure of AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka, PDB code: 4zp3 was solved by F.Goetz, Y.Roske, K.Faelber, K.Zuehlke, K.Autenrieth, A.Kreuchwig, G.Krause, F.W.Herberg, O.Daumke, U.Heinemann, E.Klussmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.50 / 2.63
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	56.922, 120.988, 57.123, 90.00, 93.01, 90.00
R / Rfree (%)	22.2 / 26.8

The binding sites of Cadmium atom in the AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka (pdb code 4zp3). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 4 binding sites of Cadmium where determined in the AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka, PDB code: 4zp3:
Jump to Cadmium binding site number: 1; 2; 3; 4;

Cadmium binding site 1 out of 4 in the AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd101 b:34.4 occ:1.00 OE1 A:GLU41 2.0 41.1 1.0 OE2 D:GLU41 2.0 28.9 1.0 OE2 I:GLU41 2.1 34.8 1.0 OE1 I:GLU41 2.2 33.0 1.0 OE1 D:GLU41 2.3 26.2 1.0 CD D:GLU41 2.5 27.4 1.0 CD I:GLU41 2.5 35.2 1.0 CD A:GLU41 2.6 38.3 1.0 OE2 A:GLU41 3.1 40.6 1.0 CG A:GLU41 3.6 37.2 1.0 CG D:GLU41 4.0 26.2 1.0 CG I:GLU41 4.0 35.5 1.0 NE I:ARG40 4.5 28.7 1.0 NE D:ARG40 4.5 22.5 1.0 NH2 D:ARG40 4.5 21.1 1.0 O D:HOH101 4.6 33.9 1.0 NH1 I:ARG40 4.6 28.4 1.0 CB D:GLU41 4.9 25.9 1.0 CZ D:ARG40 4.9 21.8 1.0 CA D:GLU41 4.9 26.5 1.0 CB A:GLU41 4.9 36.3 1.0 CB I:GLU41 4.9 36.7 1.0 CZ I:ARG40 5.0 27.9 1.0

Cadmium binding site 2 out of 4 in the AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd101 b:29.8 occ:1.00 OE2 C:GLU41 2.1 23.9 1.0 OE2 B:GLU41 2.1 32.3 1.0 OE2 J:GLU41 2.2 31.0 1.0 OE1 B:GLU41 2.2 33.1 1.0 OE1 J:GLU41 2.2 34.7 1.0 CD B:GLU41 2.5 33.2 1.0 CD J:GLU41 2.5 33.9 1.0 OE1 C:GLU41 2.5 23.6 1.0 CD C:GLU41 2.6 24.3 1.0 CG B:GLU41 4.0 34.7 1.0 CG J:GLU41 4.0 35.3 1.0 CG C:GLU41 4.1 25.7 1.0 NH1 B:ARG40 4.3 30.1 1.0 NH1 C:ARG40 4.4 24.9 1.0 NE J:ARG40 4.5 31.1 1.0 NH2 J:ARG40 4.6 30.6 1.0 NE C:ARG40 4.6 24.2 1.0 CD B:ARG40 4.7 31.3 1.0 CB B:GLU41 4.8 36.0 1.0 O C:HOH106 4.9 23.5 1.0 CB J:GLU41 4.9 35.9 1.0 CA B:GLU41 4.9 37.6 1.0 CZ C:ARG40 4.9 24.5 1.0 CA C:GLU41 5.0 27.8 1.0 CB C:GLU41 5.0 26.4 1.0 CG B:ARG40 5.0 31.3 1.0 CZ J:ARG40 5.0 30.4 1.0

Cadmium binding site 3 out of 4 in the AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka within 5.0Å range: probe atom residue distance (Å) B Occ F:Cd101 b:31.9 occ:1.00 OE2 F:GLU41 2.2 39.1 1.0 OE1 G:GLU41 2.2 30.0 1.0 OE1 F:GLU41 2.4 37.8 1.0 OE2 G:GLU41 2.5 33.6 1.0 CD F:GLU41 2.6 39.3 1.0 CD G:GLU41 2.7 32.6 1.0 CG F:GLU41 4.1 39.4 1.0 CG G:GLU41 4.2 31.7 1.0 NE F:ARG40 4.3 29.0 1.0 NH2 F:ARG40 4.4 28.8 1.0 NH1 G:ARG40 4.7 31.0 1.0 CZ F:ARG40 4.8 28.4 1.0 NE G:ARG40 4.9 29.2 1.0 CB G:GLU41 5.0 32.0 1.0 CA G:GLU41 5.0 33.0 1.0

Cadmium binding site 4 out of 4 in the AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 4 of AKAP18:Pka-Riialpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka within 5.0Å range: probe atom residue distance (Å) B Occ H:Cd101 b:30.2 occ:1.00 OE1 H:GLU41 1.6 43.4 1.0 OE2 E:GLU41 2.2 28.2 1.0 OE1 E:GLU41 2.3 31.4 1.0 CD H:GLU41 2.4 40.8 1.0 CD E:GLU41 2.6 31.9 1.0 OE2 H:GLU41 2.7 39.8 1.0 CG H:GLU41 3.8 40.3 1.0 CG E:GLU41 4.1 33.4 1.0 NE H:ARG40 4.5 29.8 1.0 NH2 H:ARG40 4.6 29.0 1.0 NH1 E:ARG40 4.8 37.4 1.0 NE E:ARG40 4.8 36.1 1.0 CB H:GLU41 4.9 38.3 1.0 CB E:GLU41 4.9 34.8 1.0 CA E:GLU41 4.9 36.5 1.0 CZ H:ARG40 5.0 29.1 1.0

F.Gotz, Y.Roske, M.S.Schulz, K.Autenrieth, D.Bertinetti, K.Faelber, K.Zuhlke, A.Kreuchwig, E.J.Kennedy, G.Krause, O.Daumke, F.W.Herberg, U.Heinemann, E.Klussmann. AKAP18:Pka-Rii Alpha Structure Reveals Crucial Anchor Points For Recognition of Regulatory Subunits of Pka. Biochem.J. V. 473 1881 2016.
ISSN: ESSN 1470-8728
PubMed: 27102985
DOI: 10.1042/BCJ20160242