Cadmium in PDB 6v37: K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure

The structure of K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure, PDB code: 6v37 was solved by L.Pope, M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.99 / 2.80
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.018, 118.735, 129.036, 90.00, 90.00, 90.00
R / Rfree (%)	27.2 / 31.7

The structure of K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure also contains other interesting chemical elements:

Potassium	(K)	5 atoms
Ruthenium	(Ru)	3 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Cadmium atom in the K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure (pdb code 6v37). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 3 binding sites of Cadmium where determined in the K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure, PDB code: 6v37:
Jump to Cadmium binding site number: 1; 2; 3;

Cadmium binding site 1 out of 3 in the K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd402 b:0.3 occ:1.00 OE2 A:GLU309 2.8 0.9 1.0 NE2 A:HIS313 3.1 0.4 1.0 CE1 A:HIS313 3.8 0.9 1.0 CD A:GLU309 4.0 0.5 1.0 CD2 A:HIS313 4.1 0.8 1.0 CG A:GLU309 4.5 0.9 1.0 ND1 A:HIS313 5.0 0.1 1.0 OE1 A:GLU309 5.0 0.8 1.0

Cadmium binding site 2 out of 3 in the K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd902 b:0.9 occ:1.00 NE2 B:HIS313 2.6 0.7 1.0 OE2 B:GLU309 2.8 0.1 1.0 CD2 B:HIS313 3.0 0.5 1.0 CD B:GLU309 3.2 0.3 1.0 OE1 B:GLU309 3.2 0.1 1.0 CE1 B:HIS313 3.5 0.5 1.0 CG B:HIS313 4.0 0.5 1.0 ND1 B:HIS313 4.2 0.8 1.0 CB B:ALA312 4.4 0.1 1.0 CG B:GLU309 4.4 0.4 1.0 O B:GLU309 4.5 0.9 1.0 CA B:GLU309 4.6 0.8 1.0 N B:HIS313 4.9 0.9 1.0

Cadmium binding site 3 out of 3 in the K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of K2P2.1(Trek-1)I110D:Rur:ML335 Bound Channel Structure within 5.0Å range:

L.Pope, M.Lolicato, D.L.Minor Jr.. Polynuclear Ruthenium Amines Inhibit K2PCHANNELS Via A "Finger in the Dam" Mechanism. Cell Chem Biol 2020.
ISSN: ESSN 2451-9456
PubMed: 32059793
DOI: 10.1016/J.CHEMBIOL.2020.01.011