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Atomistry » Cadmium » PDB 7viq-8hyf » 8chm | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Cadmium » PDB 7viq-8hyf » 8chm » |
Cadmium in PDB 8chm: Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-OneEnzymatic activity of Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One
All present enzymatic activity of Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One:
5.2.1.8; Protein crystallography data
The structure of Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One, PDB code: 8chm
was solved by
C.Meyners,
P.L.Purder,
F.Hausch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8chm:
The structure of Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One also contains other interesting chemical elements:
Cadmium Binding Sites:
The binding sites of Cadmium atom in the Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One
(pdb code 8chm). This binding sites where shown within
5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One, PDB code: 8chm: Jump to Cadmium binding site number: 1; 2; Cadmium binding site 1 out of 2 in 8chmGo back to![]() ![]()
Cadmium binding site 1 out
of 2 in the Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One
![]() Mono view ![]() Stereo pair view
Cadmium binding site 2 out of 2 in 8chmGo back to![]() ![]()
Cadmium binding site 2 out
of 2 in the Human FKBP12 in Complex with (1S,5S,6R)-10-((S)-(3,5-Dichlorophenyl) Sulfinyl)-3-(Pyridin-2-Ylmethyl)-5-Vinyl-3,10- Diazabicyclo[4.3.1]Decan-2-One
![]() Mono view ![]() Stereo pair view
Reference:
P.L.Purder,
C.Meyners,
W.O.Sugiarto,
J.Kolos,
F.Lohr,
J.Gebel,
T.Nehls,
V.Dotsch,
F.Lermyte,
F.Hausch.
Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues Jacs Au 2023.
Page generated: Thu Jul 10 15:43:01 2025
ISSN: ESSN 2691-3704 DOI: 10.1021/JACSAU.3C00241 |
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