Cadmium in PDB 9fvl: Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide

The structure of Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide, PDB code: 9fvl was solved by S.Narasimhan, S.Jansen, L.Zidek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.78 / 2.08
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	74.31, 69.108, 82.619, 90, 112.09, 90
R / Rfree (%)	23.4 / 28.3

The binding sites of Cadmium atom in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide (pdb code 9fvl). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 5 binding sites of Cadmium where determined in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide, PDB code: 9fvl:
Jump to Cadmium binding site number: 1; 2; 3; 4; 5;

Cadmium binding site 1 out of 5 in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd301 b:32.4 occ:1.00 OE1 A:GLU76 1.6 24.9 1.0 OE1 A:GLU73 2.2 25.4 1.0 OE1 A:GLN79 2.3 19.9 1.0 CD A:GLU76 2.4 33.1 1.0 OE2 A:GLU76 2.6 33.5 1.0 CD A:GLU73 3.1 36.6 1.0 CD A:GLN79 3.2 24.4 1.0 OE2 A:GLU73 3.3 41.4 1.0 NE2 A:GLN79 3.5 26.0 1.0 CG A:GLU76 3.8 36.3 1.0 CG A:GLU73 4.5 33.5 1.0 CG A:GLN79 4.6 26.4 1.0 CA A:GLU73 4.7 36.0 1.0 CB A:GLU73 4.9 35.6 1.0 N A:GLY74 4.9 34.9 1.0 CB A:GLN79 5.0 27.1 1.0

Cadmium binding site 2 out of 5 in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd302 b:33.6 occ:1.00 OE2 A:GLU154 2.3 28.3 1.0 OE1 A:GLU154 2.5 32.3 1.0 CD A:GLU154 2.7 29.3 1.0 O A:HOH471 4.0 42.6 1.0 CG A:GLU154 4.2 27.8 1.0 OE1 A:GLN150 4.4 45.0 1.0 O A:HOH425 4.6 45.8 1.0 CD2 A:LEU122 4.9 30.8 1.0

Cadmium binding site 3 out of 5 in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 3 of Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd303 b:96.7 occ:1.00 O A:HOH489 3.0 49.6 1.0 O A:HOH480 3.6 46.7 1.0 OD1 A:ASP146 3.7 52.8 1.0 OD2 A:ASP146 4.0 47.5 1.0 CG A:ASP146 4.3 40.5 1.0

Cadmium binding site 4 out of 5 in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 4 of Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd301 b:33.1 occ:1.00 OE2 B:GLU84 1.9 36.6 1.0 OE1 B:GLU87 2.4 36.3 1.0 OE2 B:GLU87 2.6 37.7 1.0 CD B:GLU87 2.8 32.5 1.0 CD B:GLU84 2.9 45.6 1.0 CG B:GLU84 3.5 43.4 1.0 OE1 B:GLU84 4.1 63.7 1.0 CG B:GLU87 4.3 29.7 1.0 CA B:GLU84 4.7 30.9 1.0 CG B:ARG83 4.8 37.3 1.0 CB B:GLU84 4.8 33.6 1.0 CD B:ARG83 4.9 34.5 1.0

Cadmium binding site 5 out of 5 in the Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 5 of Dimeric 14-3-3 Zeta in Complex with Unphosphorylated MAP2C Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd302 b:33.6 occ:1.00 OE1 B:GLU76 1.7 24.1 1.0 OE1 B:GLU73 2.0 31.6 1.0 OE1 B:GLN79 2.3 23.3 1.0 CD B:GLU76 2.4 36.2 1.0 OE2 B:GLU76 2.6 30.7 1.0 CD B:GLU73 2.9 44.1 1.0 CD B:GLN79 3.2 28.6 1.0 OE2 B:GLU73 3.2 44.4 1.0 NE2 B:GLN79 3.4 27.9 1.0 CG B:GLU76 3.9 44.9 1.0 CG B:GLU73 4.3 40.6 1.0 O B:HOH471 4.5 47.3 1.0 NH1 B:ARG83 4.5 44.7 1.0 CG B:GLN79 4.6 29.6 1.0 OE1 B:GLN80 4.7 38.8 1.0 O B:HOH440 4.7 46.9 1.0 CA B:GLU73 4.7 40.7 1.0 N B:GLY74 4.8 43.6 1.0 CB B:GLU73 4.8 41.1 1.0 CB B:GLN79 5.0 28.2 1.0 CB B:GLU76 5.0 43.5 1.0

S.Jansen, S.Narasimhan, P.Cabre Fernandez, L.Ilkovicova, A.Kozelekova, K.Kralova, J.Hritz, L.Zidek. Characterization of Multiple Binding Sites on Microtubule Associated Protein 2C Recognized By Dimeric and Monomeric 14-3-3 Zeta. Febs J. 2025.
ISSN: ISSN 1742-464X
PubMed: 39877981
DOI: 10.1111/FEBS.17405