Cadmium in PDB 1q8a: Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met)

All present enzymatic activity of Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met):
2.1.1.13;

The structure of Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met), PDB code: 1q8a was solved by J.C.Evans, D.P.Huddler, M.T.Hilgers, G.Romanchuk, R.G.Matthews, M.L.Ludwig, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.70
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	59.120, 86.190, 126.080, 90.00, 99.99, 90.00
R / Rfree (%)	21.4 / 24.2

The binding sites of Cadmium atom in the Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met) (pdb code 1q8a). This binding sites where shown within 5.0 Angstroms radius around Cadmium atom.
In total 2 binding sites of Cadmium where determined in the Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met), PDB code: 1q8a:
Jump to Cadmium binding site number: 1; 2;

Cadmium binding site 1 out of 2 in the Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 1 of Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met) within 5.0Å range: probe atom residue distance (Å) B Occ A:Cd601 b:21.4 occ:1.00 SG A:CYS272 2.4 16.4 1.0 SD A:HCS701 2.5 14.0 1.0 SG A:CYS273 2.6 23.0 1.0 SG A:CYS207 2.7 22.3 1.0 CB A:CYS207 3.4 16.6 1.0 CG A:HCS701 3.4 19.1 1.0 N A:CYS273 3.6 21.5 1.0 CB A:CYS273 3.7 20.3 1.0 CB A:CYS272 3.8 19.5 1.0 CB A:HCS701 3.9 17.2 1.0 OD1 A:ASN234 4.0 22.1 1.0 CA A:CYS273 4.2 20.7 1.0 CA A:CYS207 4.3 18.6 1.0 ND2 A:ASN206 4.4 13.8 1.0 C A:CYS272 4.6 21.2 1.0 CA A:CYS272 4.6 19.4 1.0 OG1 A:THR147 4.8 15.3 1.0 N A:CYS207 5.0 16.5 1.0

Cadmium binding site 2 out of 2 in the Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met)


Mono view


Stereo pair view

A full contact list of Cadmium with other atoms in the Cd binding site number 2 of Cobalamin-Dependent Methionine Synthase (1-566) From Thermotoga Maritima (CD2+:L-Hcy Complex, Se-Met) within 5.0Å range: probe atom residue distance (Å) B Occ B:Cd602 b:23.7 occ:1.00 SG B:CYS272 2.4 19.7 1.0 SG B:CYS207 2.5 30.6 1.0 SD B:HCS702 2.5 15.8 1.0 SG B:CYS273 2.6 25.9 1.0 CB B:CYS207 3.4 23.0 1.0 CG B:HCS702 3.4 21.4 1.0 N B:CYS273 3.6 21.9 1.0 CB B:CYS273 3.7 24.7 1.0 OD1 B:ASN234 3.7 36.5 1.0 CB B:CYS272 3.8 21.2 1.0 CB B:HCS702 3.9 18.9 1.0 CA B:CYS273 4.2 23.9 1.0 CA B:CYS207 4.4 23.7 1.0 ND2 B:ASN206 4.5 20.2 1.0 C B:CYS272 4.6 23.0 1.0 CA B:CYS272 4.6 21.4 1.0 CG B:ASN234 4.7 35.5 1.0 OG1 B:THR147 4.9 19.3 1.0

J.C.Evans, D.P.Huddler, M.T.Hilgers, G.Romanchuk, R.G.Matthews, M.L.Ludwig. Structures of the N-Terminal Modules Imply Large Domain Motions During Catalysis By Methionine Synthase. Proc.Natl.Acad.Sci.Usa V. 101 3729 2004.
ISSN: ISSN 0027-8424
PubMed: 14752199
DOI: 10.1073/PNAS.0308082100